Is there anything recommended that works out of the box.
Looks like a simple "out of the box" solution doesn't exist for that. I you want to put some work in, try to start from beginning. Remove all devices from USB but the remote's dongle, install the latest 13 nightly to an SD card. Make only the basic settings and try the remote for a while. If working well, try to add back, step by step the USB devices, install addons. If you could find what trigger the issue with the remote, you are a step closer to find a solution.