Out of pure curiosity I powered up my Rpi4-8gb running LE11.01 then powered up a USB connected 2TB external HD GPT /ntfs system and no issues to report. Could the drive size be a factor?
I have Pi4 with 4x6TB running without any issues, even one with atm 8x4TB that on occasions runs with 16x4TB, havent seen any problems with any of them yet.