Audio is a bit tricky.
It's best to leave the EDID of the second HDMI port as is (using "getedid create" to fetch and force the EDID read from the AVR etc is fine), so it's using the info from the connected AVR/audio extractor/... - it you use some display mode not supported by the AVR, force some speaker allocation that doesn't match what's connected to the AVR etc things will go south.
For the EDIDs used by the first HDMI port / monitor it's best to create 3 different ones for 2.0, 5.1 and 7.1 setups (this is eg also what my HDFury VRROM offers in it's built-in EDIDs).
Enabling higher sample rates than 48kHz or compressed formats like AC3, DTS, MLP etc shouldn't hurt but keep in mind that there are audio bandwith limitations on the lower res modes. 720p50 and above will do 192kHz 8ch fine, but modes below are quite limited (eg 640x480p60 only allows up to 8ch 48kHz or 2ch 192kHz) - IIRC there's some info about that in HDMI or CEA specs.
If you use some HDMI audio extractor or similar (or even just a TV/monitor with audio capability) you'll also have to test if it actually works with the custom modes you added - some may only work fine with the standard HDMI modes but not with anything else.
so long,
Hias