I've just done a full clean install of LE 10 onto a Pi4 (booted via USB) and have noticed that from time to time I get significant input lag of my TV's remote control via CEC over HDMI. I've been running LE 9 on this same Pi4 for ages and this didn't happen.
It usually happens after the Pi has been idle and the screen saver is showing; the remote's input will work for a few seconds, then there will be a lag period of around 4-6 seconds where none of the inputs will register on the UI, then they will all flood in at once. The inputs are obviously delayed in a buffer, waiting to be processed.
I've had a look at the CEC input settings and can't see anything that would cause this, and the CEC settings are the same as another Pi3 I have running LE 9 attached to the same TV via HDMI and also controlled via CEC. I haven't bothered looking at any logs yet, as it's just a mild annoyance at the moment, but maybe it might be something others have experienced with the new LE 10 release and CEC.