I'm not sure there will be much add-on breakage with Omega. Kodi devs are generally running their own code so anything from the Kodi repo normally works fine, and there are no major API differences between Nexus/Omega (so far) to cause disruption with other add-ons; the Py2 to Py3 changes are long done and settled now. One change that will happen in LE12 is a switch from arm to aarch64 userspace as 64-bit widevine libs have finally appeared.
On the kernel side, if there's anything notable to backport from newer kernels to 6.1.y then it can be done. I plan to send at least one more bump for LE 11.0.1 to resolve the "pink line" seen on S912 boards when scaling SD media to 1080p. I'm not expecting much progress to happen on hardware decoders in the near future though.
NB: I will probably close this thread and fork a new one for K21 images soon. I do need to move the kernel codebase forwards to drop patches and ensure I'm not sitting on too much technical debt.