It could depends on my bad English, but what should I expect under a „Multi USB powered hub“ ? It‘s a powered hub? Or a USB hub which gets the power from 1 or multiple USB ports of the RPi5 only? No external power supply?
If the answer for the last question is „yes“, it sounds critical to me, because the RPi5 alone needs a stronger power supply 27W than the RPi4 (18W). And you will drive 4 additional USB drives. This could be far away of the official current specification for a USB port or the RPi5 board itself.
If you are still below the current limit of the RPi5 USB ports and your power supply is powerful enough, do you know about this config.txt settings?
https://www.raspberrypi.com/documentation/computers/raspberry-pi.html#differences-on-raspberry-pi-5
usb_max_current_enable=1
and in EEPROM config:
https://www.raspberrypi.com/documentation/computers/raspberry-pi.html#PSU_MAX_CURRENT
PSU_MAX_CURRENT=5000
One of the other possibilities is, that something regarding the NTFS support was changed with the recent kernels.