Today I was able to test a USB DVD drive on my Ubuntu Linux PC (VLC player), using region code 1 and 2 DVD's. Some DVD's work, some don't. On Windows 10 (64 bit), using the built in "Windows DVD-Player", some DVD's don't work, too.
Funny thing: My internal PC DVD player works with some DVD's, who are unable to start in the external DVD player. I think the DVD copyright protection produces different results on different DVD drives.
So, there is no more need to try the USB DVD drive on Raspberry Pi - the drive failed. It's a game of luck (different DVD copyright protection), if some DVD works or not.
I have to use a stand-alone region-free DVD player. It's a libdvdcss and hardware issue, not a LibreELEC issue. Problem solved.