In theory de-featuring the board to a single HDMI connector shouldn't be an issue, but if you fuzzed one thing it's possible other things were damaged too. Historically i'm able to play 4K30 VP9 content from YouTube, although I didn't test since the rather niche regression below was possibly added (and can't test from current location).
There is one software regression we are triaging, noted when playing 4K H264 on an RPi5; much higher resolution than 720p VP9 but also software decoding so there's a chance your issue could be the same thing. Log in to the RPi5 over SSH, run rpi-eeprom-config -e and add SDRAM_BANKLOW=3 to the end of the file, then reboot. Any better after? NB: If no difference, it's not the same issue and you can revert the change.