I'm wondering if the audio glitch is similar to the N100 issues here: https://github.com/LibreELEC/LibreELEC.tv/pull/8588 - the script in that PR is not going to be merged as it's too much of a hack, but you could copy/paste it locally and experiment. It basically finds the active DRM connector and limits the max bits-per-pixel to 10-bit as 12-bit seems to cause issues. The root cause is unknown but I have a hunch it's related to bandwidth and UHD video + HD audio maxes out something resulting in audio dropouts.
You might want to add something like video=HDMI-A-1:1920x1080M@60 to kernel boot params in syslinux.cfg in case (for reasons unknown) the box is trying to use a problematic 4K mode. This will clamp initial kernel DRM output to 1080@60 to stop that. There's no impact on Kodi switching to 4K during playback later.