Could you please give this test build a try? LibreELEC-RPi4.arm-9.80-devel-20210124165749-4b10646.tar
It includes a couple of patches to trying to fix issues we've seen (audio FIFO overfilling, audio buffer underrun in kodi) and also includes a patch to periodically check for HDMI FIFO issues.
If you run into audio dropouts please upload a pastekodi log. BTW: no need to enable audio or video component logging in kodi, that won't reveal anything interesting and just bloats the log.
so long,
Hias