Can you describe what installation image you are using, and what happens when you boot the image from stick? If it's a real installer, there should appear the option to install on your HDD.
PS: If you don't see any target drives to install, reformat your HDD with a tool like "GParted Live". You can run it from stick, too. It's interesting whether the tool can "see" your HDD while running from stick.
The result should be a single, error-free partition (ext3 for example) with no boot flag set. Try to run the LE installer on that setup.
I'm using a 350gb hard drive, hooked up on a usb adapter I use to read hard drives and program them for pcs. It reads like a usb drive! But the libreelec creator won't pick it up, no matter how it's formatted 32gb 64gb or full 320 will recheck ntfs or fat only other factors that I can think of! Otherwise I should be able to program the drive and install it straight to the pc and run like a os