Works fine for me with a chromebox with libreelec.
There seems to be a problem with the latest Harmony software. I have two Asus boxes; one runs the latest alpha, the other runs Milhouse builds. Both worked fine with the Harmony hub. Today I did a clean install on the Milhouse box and the Harmony remote (keyboard) is not recognized. Every other BT device I have pops up immediately -- even my iPhone which has the Harmony app.
On the Mac, the myHarmony app now longer works -- you can't sign in, and the logitech website is pretty much broken, including the forums. Probably they will get around to fixing this but I'm really glad I have two Chromeboxes. Not holding my breath.