Yes. Maybe. No.
Answer will depend.
In my case - I run nightly+ on my daily system (Generic ADL) , but am developing everyday as you would see. The operating system is starting to take shape for the LE13 release, in that the big changes - compilers, libraries, kernels are pretty much done. So no major changes at the operating system level that would impact are expected. We will be updating to the next Mesa soon.
As a developer, I run RC software packages, so that we try and address issues with “new packages” before they are released - thus I try to be on the front foot so that the commits are soak tested first. The team in both Kodi and LE do the same.
There are kodi changes happening (api) that will mandate changes/updates to addons, and this will continue through to the release of Kodi Piers. These may cause you to have to update - if you use these.
You will need to decide what’s best for you, but if you stay on a version “eg the early sept one” and don’t have fixed the issue you are trying to address, then when the LE13 does come out, the issue may still not be fixed in the release version. In the case of using “new hardware”, I would stay using recent nightlies, to make sure that they work with your system. Older hardware is usually more stable in the linux kernels/graphics software.
based on Chewitts answers - I would fix your system so that it can play all, as if there is another issue that comes, it might not get fixed. If there is a further problem that is not whitelist. So GUI in 1920x1080 and whitelist max 3840x2160.