I just setup my Pi 5 with a pineberry HatDrive! and a tiny NVME drive. It runs like a champ and loads all of my thumbs pretty much instantly. Running LE11 - 4kHDR and HD audio work perfectly. After futzing around with x86 for the past couple years, this is by far the best, easiest solution I’ve found.
The only problem is my flirc case doesn’t fit with the HatDrive! on top.